The relationship between gut microbiota and diabetes has attracted increasing attention from researchers. Several studies have shown that the imbalance of gut microbiota may be closely related to the development and course of diabetes.

On the one hand, intestinal flora is involved in the regulation of energy metabolism and glucose homeostasis of the host. When beneficial bacteria such as Bifidobacterium and Lactobacillus are reduced, and toxin-producing bacteria such as Bacteroides and Clostridium tender are increased, it may lead to increased intestinal permeability, trigger systemic inflammatory response, and then affect insulin sensitivity and blood glucose control, and aggravate diabetes. On the other hand, gut microbiota may also influence the development of diabetes by regulating the immune response and endocrine system. For example, some intestinal bacteria can induce T cell differentiation into Th17 cells, promote the production of cytokines, these factors in the development of insulin resistance and type 1 diabetes play a key role.

In addition, some studies have found that the diversity and abundance of intestinal flora are different in patients with type 2 diabetes compared with non-diabetic patients, which may be related to insulin resistance and abnormal glucose metabolism. Therefore, gut microbiota may be an important intervention point in diabetes. Improving the balance of gut microbiota through dietary modification, prebiotic intake, probiotic supplementation, and gut microbiota transplantation (FMT) may help to prevent and treat diabetes.

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